Dissertation to Journal Article: A Systematic Approach

How to Read a Medical Journal Article

When you are assessing the quality of the evidence, it’s not how the data are analyzed that’s important. Far more important is how the data are collected. Don’t agonize over whether the researchers should have used a non-parametric test or whether a random effects meta-analysis is appropriate (just to cite two obscure examples). These are important issues and they generate a lot of debate. But ...

Journal Article

Four lines of evidence support a central role for H. pylori and PUD: (1) the natural history of H. pylori infection, (2) epidemiologic data, (3) outcomes after cure of H. pylori infection in patients with PUD, and (4) the frequent development of gastric ulcers in H. pylori-infected Mongolian gerbils. With so much circumstantial evidence and with Koch's postulates arguably fulfilled for a direct...

Journal Article

Journal Article

It is now recognized that there is a two-way interaction between Helicobacter pylori gastritis and gastric physiology. H. pylori gastritis can alter gastric physiology, leading to increased or decreased acid secretion depending on the pattern of gastritis present. These changes in physiology are related to the disease outcome, with increased acid secretion leading to duodenal ulcer disease and ...

Journal Article

During the past 20 years, endoscopy has developed as the modality of choice for determining diagnosis, prognosis, and therapy for severe gastrointestinal bleeding. When endoscopy was first introduced to evaluate gastrointestinal bleeding in the late 1970s, early diagnostic endoscopy did not affect patient outcome. [46] Subsequently, improvements in endoscopes and endoscopic accessories allowed ...